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Differences Between Tizanidine Zanaflex and Flexeril

In some circumstances, tizanidine might be used safely in this case. Health insurance plans usually cover the generic forms of both drugs without prior authorization. In many cases, insurance companies will require a prior authorization for Zanaflex or Amrix (a current brand name for extended-release cyclobenzaprine). Generally, the brand-name drugs are more expensive than the generics. Between the generics, tizanidine may be slightly more expensive than cyclobenzaprine.

Tizanidine is an oral drug that is available both in generic and brand name. It is a type of muscle relaxant used for very specific types of muscle spasms. These are muscle spasms caused in people with spinal cord injuries and Multiple Sclerosis. Antispastic medications are effective in treating flexeril and doxycycline spasticity, but high doses can lead to unwanted side effects. Other treatments can help with spasticity as well, including physical therapy and Botox® injections. Four popular muscle relaxants are Flexeril (cyclobenzaprine), baclofen, Robaxin (methocarbamol), and Zanaflex (tizanidine).

Its action on these neurotransmitters may also contribute to its sedative effects – this can be beneficial for patients who have difficulty sleeping due to their muscle spasms. Muscle tightness, tension, and pain usually arise due to muscle spasms and spasticity. Although various factors can cause it, muscle spasm is a common symptom of most musculoskeletal conditions. Tizanidine vs. Flexeril are both FDA-approved skeletal muscle relaxants and both belong to prescription-only drugs. Physicians usually start patients off at lower doses and increase their doses, as necessary.

  • In comparison, Flexeril can be taken in doses from 5-10mg three times per day but should not exceed a total of 30mg per day.
  • If you have symptoms of overdose, call 911 or go to the nearest emergency room.
  • In many cases, insurance companies will require a prior authorization for Zanaflex or Amrix (a current brand name for extended-release cyclobenzaprine).
  • It’s believed to work by attaching to a receptor or protein in the brain called the alpha-2 receptor, which reduces the release of substance P in your brain and spinal cord.
  • They are both administered to treat sustained muscle contractions due to debilitating musculoskeletal conditions like multiple sclerosis.
  • In comparison, Tizanidine is more direct – blocking the nerve signals in the brain, reducing activity of the muscles that cause muscles to spasm.

However, it should only be used short-term (up to two or three weeks), as its effectiveness beyond this time period has not been proven. Deciding between the two depends on factors such as the type of muscle spasm or pain you are experiencing and their possible side effects and dosing. Therefore, we always suggest consulting your doctor before choosing either of these medications. Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. AddictionResource fact-checks all the information before publishing and uses only credible and trusted sources when citing any medical data.

At what dose is Zanaflex typically prescribed?

Tizanidine and Flexeril are both muscle relaxers that can be used with a physical therapy program. If your doctor has presented these options to you, you may be considering which one is right for you and wondering how they compare. Read on to find out what each drug does so that you are informed when you speak with your doctor about the best medication to take. Zanaflex and Flexeril are both effective drugs for muscle spasms and muscle pain.

Certain medications are better than others for managing spine pain – Harvard Health

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It’s usually caused by damage to nerve pathways within your brain or spinal cord that control movement and stretch reflexes. However, in general, Tizanidine is considered to have a stronger muscle relaxant effect compared to Cyclobenzaprine. Tizanidine acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine’s side effects.

Xanax also reacts with grapefruits, grapefruit juice, and alcohol to cause severe side effects. In comparison, Zanaflex vs. Xanax are both fast-acting and act by diminishing the sensitivity of specific receptors in the brain. Cyclobenzaprine counts as a preferred and safer alternative to Zanaflex due to its fewer side effects and interactions with other drugs. There are no adequate studies done on tizanidine to determine safe and effective use in pregnant women.

Can you mix ibuprofen and alcohol?

While OTC and natural alternatives are helpful and can be used with more potent muscle relaxants, it is essential to seek medical advice before starting or combining them. Muscle relaxers are non-narcotic, but that doesn’t mean they aren’t addictive. People can and do get addicted to muscle relaxers and other prescription drugs.

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They also share some common side effects, such as drowsiness, dizziness, and stomach agitation. Flexeril, on the other hand, is not recognized by medical professionals as addictive, but there is evidence that it may be possible to get addicted to it. In high doses, Flexeril can produce calming and pain-relieving effects that are desirable by some people, and this is part of the reason it was only meant to be used for short periods of time. Abruptly stopping Flexeril can lead to undesirable symptoms of withdrawal.



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